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Discovery target SEA
This flying disc goal is an ovoid target adjustable to 3 different heights: from 88 to 135cm. The base can be weighted with water or sand. It offers multiple game combinations, used alone as a target or in doubles for accuracy events. Delivered with 6 discs.
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Polypharmacology : Strategies for Multi-Target Drug Discovery
Practical guide to navigate problems involved with promiscuous ligands and multi-target drug discovery, supported by case studies and real examples Polypharmacology covers the two-sided nature of polypharmacology: its relevance for adverse drug effects, as well as its benefit for certain therapeutic drug classes in effectively treating complex diseases like psychosis and cancer.The book provides practical guidelines and advice to help readers design drugs that have multiple targets while minimizing unwanted off-target effects, discusses important disease areas like viral infection, diabetes, and obesity that have advanced significantly in the last decade, and guides researchers in neighboring areas to polypharmacology.The book is divided into four parts. Part A covers the link between off-targets and adverse drug reactions, how to screen for off-target activity, and how to recognize and optimize compounds with a potential for off-target activity.Part B discusses disease areas which benefit from polypharmacological approaches.Part C highlights important approaches, such as compound design, data mining with web-based tools, and multi-target peptides.Part D provides case study coverage on topics like CDK4/6 inhibitors for cancer treatment, the potential of multi-target ligands for COVID, and protein degraders and PROTACs.Sample topics discussed in Polypharmacology include: Molecular properties and structural motifs in pharmacological promiscuity, covering lipophilicity, molecular weight, and other parametersKinase liabilities in early drug discovery, covering core kinases driving the cell division cycle and consequences of interference, and cell cycle checkpoints controlling cell divisionTreatment of major depressive disorder, covering tricyclic antidepressants, monoamine oxidase inhibitors, and selective serotonin and norepinephrine reuptake inhibitorsTrends in the field, such as novel antipsychotics, standardization of screening tools, and the SmartCube System®, as well as lessons from history Delivering the latest research developments in the field, Polypharmacology is an essential reference on the subject for medicinal chemists, pharmacologists, biochemists, computational chemists, and biologists, as well as pharmaceutical professionals involved in drug discovery programs.
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Target Discovery and Validation : Methods and Strategies for Drug Discovery
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation.With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods.Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research.This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume.It also includes numerous practical examples.
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New Shooting Target Outdoor Hunting Target Set Useful Target military target (6pcs) gz330027
New Shooting Target Outdoor Hunting Target Set Useful Target military target (6pcs) gz330027
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Do tanks target automatically?
Tanks do not target automatically. They require human input to identify and engage targets. Tank operators use various sensors and targeting systems to locate and track potential threats, and then they manually aim and fire the tank's weapons. While some modern tanks may have advanced targeting and fire control systems, the decision to engage a target is ultimately made by the tank crew.
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Series like Star Trek: Discovery
Series like Star Trek: Discovery are typically science fiction shows that explore themes of space exploration, advanced technology, and diverse alien cultures. They often feature a diverse cast of characters and focus on moral and ethical dilemmas faced by the crew. These series also tend to have high production values, intricate storylines, and a mix of action and drama. Fans of Star Trek: Discovery may enjoy other similar shows like The Expanse, Battlestar Galactica, and Doctor Who.
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What are eye and target?
In the context of marketing and advertising, "eye" refers to the attention or focus of a consumer or audience on a particular product, brand, or message. It represents the ability of a marketing campaign to capture and hold the attention of potential customers. On the other hand, "target" refers to the specific demographic or audience that a marketing campaign is aiming to reach and influence. This could include factors such as age, gender, income level, geographic location, and interests. Both "eye" and "target" are important concepts in developing effective marketing strategies and campaigns.
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What is a math target?
A math target is a specific skill or concept that a student is working towards mastering in mathematics. It is a goal that helps guide the student's learning and progress in a particular area of math. Math targets can be set by teachers to help students focus on specific areas of improvement and track their progress towards achieving mastery. By setting clear math targets, students can work towards improving their understanding and proficiency in math.
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New Shooting Target Outdoor Hunting Target Set Useful Target military target (6pcs) gz330027
New Shooting Target Outdoor Hunting Target Set Useful Target military target (6pcs) gz330027
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Training target Pure2Improve target trainer
pure2improve target trainer. black with red ball. flexible bungee. hooks easily attach to net hooks with no tools required. bright red, ball sits directly in the center. material: 70% pu, 15% plastic, 10% prolypropylene, 5% pom. packed in c
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BN Sanda Foot Target Taekwondo Extended Hand Target Children's Boxing Target Home Hand Target Boxing Leg Target Arc Dual Purpose Target a pair black
Package list: 1 x Protective Gear; Product category: Boxing gloves Applicable scene: boxing+fighting+Taekwondo+Sanda For children only: No
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3 pcs stainless steel target steel small steel people target metal target alloy practice target
3 pcs stainless steel target steel small steel people target metal target alloy practice target
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What is a target image?
A target image is a reference image or a desired outcome that a person or a system aims to achieve or replicate. It serves as a benchmark or a goal to work towards. In various fields such as computer vision, machine learning, and image processing, a target image is used as a comparison point for evaluating the performance of algorithms or models. By comparing the output of a system to the target image, one can assess the accuracy and effectiveness of the process.
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How can one target Porsche?
One can target Porsche by conducting market research to understand the brand's target audience and their preferences. Developing a marketing strategy that highlights Porsche's unique selling points, such as luxury, performance, and craftsmanship, can help attract potential customers. Utilizing digital marketing channels, such as social media and online advertising, can also help reach a wider audience interested in luxury cars like Porsche. Additionally, collaborating with influencers or partnering with luxury brands can help increase brand visibility and appeal to a more affluent demographic.
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What are target text formats?
Target text formats refer to the specific types of documents or files that a text may need to be converted into or formatted as. This could include formats such as PDF, Word document, HTML, or plain text. Target text formats are important to consider when translating or localizing content to ensure that the text is presented in the appropriate format for its intended use or audience.
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Which target group uses Facebook?
Facebook is used by a wide range of target groups, but it is most popular among young adults and middle-aged individuals. The platform is commonly used by people aged 18-49, with a slightly higher percentage of women than men. Additionally, Facebook is popular among individuals with varying levels of education and income. Overall, Facebook's user base is diverse and includes people from different demographics and backgrounds.
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